Nuclear physicians through the visual assessment of radiotracer uptake conventionally evaluated SPET and PET studies of cerebral perfusion and metabolism in neurological patients Such visual inspection can be overcome by qualitatively and , semi-quantitatively evaluations based on the definition of Regions Of Interest (ROIs) positioned in cerebral areas with apparently abnormal uptake, and by asymmetry indices (e.g. ratio between ROI in areas corresponding within the two cerebral hemi-spheres). These methods are limited due to the subjectivity evaluation, and to the time requested for ROI processing in semi-quantitative analysis. In the last years, the need for a quantitative automatic method for the evaluation of SPET and PET cerebral studies becamemandatory. In order to answer to this request, pixel-by-pixel statistical methods, based on the comparison between PET or SPECT brain studies of a single subject with a database of normal subjects have been largely used. In particular, for this purpose, the Statistical Parametric Mapping (SPM) method has been applied in functional neurology d. The Functional Imaging Lab (FIL) in London has first developed SPM, for the analysis of cerebral activation studies with PET and fMRI, with the aim of assess the cerebral regions engaged in specific cognitive tasks. Basically, SPM application to cognitive activation studies consists into the statistical evaluation of cerebral regions with increased blood flow or metabolism with respect to baseline condition. The use of SPM can be extended to studies in individual neurological patients for the recognition of hypo-perfusion or hypo-metabolism pattern with respect to normal subjects. SPM can be used for the assessment of neurodegenerative disorders, and in particular for the diagnosis of Alzheimer diseases, as described in the publications presented in the section devoted to the use of SPM in Neurology.